Epigenetics, Aging, Evolution, and Environmental Science
My research is multi-scale with studies at the molecular genetic level in multiple organisms and human populations. I use computational methods to predict changes to the epigenome caused aging, dietary interventions, and environmental toxicants. I focus on both gene promoters and repetitive elements. My research models, the mouse and human, are primarily impacted by dietary shifts in nutrient availability and quantity simultaneously with toxicant exposure. My data analysis leverages massively parallel sequencing with comparative genomics to reveal regions evolutionarily selected for environmental plasticity.