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The goals of my research are to identify environmentally induced epigenetic changes arising from dietary or toxicological exposure in early development that result in lifelong health consequences. My strategy is to leverage the tools of evolutionary genomics, molecular genetics, and bioinformatics to discover interindividual differences independent of underlying genetic polymorphisms. My research is multi-level, traversing from the molecular level, to whole organisms (human and mouse), through to human epidemiology and comparative genomics. My lab will encompass the fields of nutrition, interspecies epigenetic evolution, and toxicant induced shifts to regions of heightened epigenetic sensitivity in early development. The rapid progress in next-generation sequencing, growing computational speed and storage, the increase in non-model organism genomes sequence availability, as well as advances in statistical analyses, allow my research program to address previously unaddressable questions.